LUJO HEMORRHAGIC FEVER

Clinical Features and Patient Management of Lujo Hemorrhagic Fever

BACKGROUND In 2008 a nosocomial outbreak of five cases of viral hemorrhagic fever due to a novel arenavirus, Lujo virus, occurred in Johannesburg, South Africa. Lujo virus is only the second pathogenic arenavirus, after Lassa virus, to be recognized in Africa and the first in over 40 years. Because of the remote, resource-poor, and often politically unstable regions where Lassa fever and other ...

Genetic Detection and Characterization of Lujo Virus, a New Hemorrhagic Fever–Associated Arenavirus from Southern Africa

Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fatality rate of 80% (4/5 cases). Unbiased pyrosequencing of RNA extracts from serum and tissues of...

Severe Hemorrhagic Fever in Strain 13/N Guinea Pigs Infected with Lujo Virus

Lujo virus (LUJV) is a novel member of the Arenaviridae family that was first identified in 2008 after an outbreak of severe hemorrhagic fever (HF). In what was a small but rapidly progressing outbreak, this previously unknown virus was transmitted from the critically ill index patient to 4 attending healthcare workers. Four persons died during this outbreak, for a total case fatality of 80% (4...

Ebola Hemorrhagic Fever and Marburg Hemorrhagic Fever

media coverage when outbreaks occur. The causative organisms are found in tropical Africa and the Philippines. They belong to the Filoviridae family. Clinical presentations of the viral infections they cause share many common characteristics. At least 6 Marburg virus outbreaks and 21 Ebola virus outbreaks have been documented to date (Table 1). More outbreaks have probably occurred in remote ar...

[Hemorrhagic fever with renal syndrome (Korean hemorrhagic fever)].